Process for the preparation of purified albumin solutions

Details Process for the preparation of purified albumin solutions Process for the preparation of purified albumin solutions

1991-10-11

2000-02-08

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Albumin

530363, 530412, 530416, 530427, A61K 3800, C07G 700

Patent

active

060229543

ABSTRACT:
The invention relates to a process for preparing purified albumin from a human or animal physiological solution, such as a plasma or a plasma fraction. The process includes a process of delipidation using an anionic detergent and two chromatographic separation stages using ion-exchange resin. By applying the process according to the invention, it is possible to obtain an albumin solution of great purity, that is stable and suitable for therapeutic use.

REFERENCES:
patent: 3992367 (1976-11-01), Plan et al.
patent: 4086222 (1978-04-01), Lindquist et al.
patent: 4228154 (1980-10-01), Fisher et al.
patent: 4675384 (1987-06-01), Dromard et al.
Berglof et al., J. Appl. Biochem. vol. 5 No. 4-5, pp. 282-292 (1983).
J.M. Curling, Methods of Plasma Proteins Fractionation ed. Curling, Academic Press, London, pp. 77-91, 1980.
L. Martinache et al., Separation of Plasma Proteins ed. Curling, Pharmacia Fine Chemicals AB Upsala, Sweden, pp. 43-126, 1983.
J.M. Curling et al., Pharmacia Fine Chemicals, AB Upsala, Sweden, vol. 33, pp. 97-107, 1977.
World Patent Index Abstract, JP 57-095997 A, Nihon, Jun. 1982.

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