Process for the preparation of pure risedronic acid or salts

Details Process for the preparation of pure risedronic acid or salts Process for the preparation of pure risedronic acid or salts

2007-05-09

2011-12-13

Andres, Janet (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S102000

Reexamination Certificate

active

08076483

ABSTRACT:
The present invention relates to an industrially advantageous process of making bisphosphonic acid or its salt in particular risedronic acid, [1-hydroxy-2(3-pyridinyl)ethylidene]bisphosphonic acid, having formula-(I) or its salts in high purity and high yields.

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Kieczykowski, G.R., et al., 1995, “Preparation of (4-Amino-1-Hydroxybutylidene)bisphosphonic Acid Sodium Salt, MK-217 (Alendronate Sodium). An Improved Procedure for the Preparation of 1-Hydroxy-1,1-bisphosphonic acids,” The Journal of Organic Chemistry, 60(25): 8310-8312.

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