Process for the preparation of pure N,N'-asymmetrically substitu

Details Process for the preparation of pure N,N'-asymmetrically substitu Process for the preparation of pure N,N'-asymmetrically substitu

1992-07-31

1994-02-01

Raymond, Richard J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564 47, 564 50, 564 52, 564 53, 564 54, 548200, 548538, 546226, 544390, 544165, 544 59, C07C27318, C07C27526, C07C27528

Patent

active

052833623

ABSTRACT:
Process for the preparation of very pure ureas of the formula phenyl--(NH--CO--NR.sub.1 R.sub.2).sub.n in which phenyl represents an unsubstituted or substituted phenyl or phenylene group and R.sub.1 and R.sub.2 are either identical and each represent an alkyl group, or are different, in which case R.sub.1 represents a hydrogen atom and R.sub.2 represents an alkyl or phenyl group, or R.sub.1 and R.sub.2, together with the nitrogen atom, represent an aliphatic heterocyclic ring and n is the number 1 or 2, by reacting a phenylurea of the formula phenyl--(NH--CO--NH.sub.2).sub.n with an amine of the formula NR.sub.1 R.sub.2 H at temperatures from 100 to 200.degree. C. in a diluent which is inert under the reaction conditions, the reaction being interrupted before by-products are formed, and the urea which is formed being removed from the starting compounds, and the unreacted starting compounds being returned to the process if appropriate.

REFERENCES:
patent: 3935258 (1976-01-01), Hempel et al.
patent: 4410697 (1983-10-01), Torok et al.
patent: 4814499 (1989-03-01), Parron
patent: 5043444 (1991-08-01), Mullner et al.
patent: 5091553 (1992-02-01), Mullner et al.
patent: 5099021 (1992-03-01), Worther et al.
Davis et al., "J. Am. Chem. Soc.", 44 2595 (1922).

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