Process for the preparation of pure anastrozole

Details Process for the preparation of pure anastrozole Process for the preparation of pure anastrozole

2011-08-02

2011-08-02

Saeed, Kamal (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07989636

ABSTRACT:
A process for the preparation of anastrozole which comprises: a) brominating 3,5-bis(2-cyanoprop-2-yl)toluene (II) in an organic solvent using a brominating agent to obtain 3,5-bis(2-cyanoprop-2-yl)benzylbromide (III); b) heating the reaction mass of step a) to the reflux temperature of the organic solvent for a period of time no longer than 3 hours; c) isolating and purifying the bromo intermediate (III) using an organic solvent; d) alkylating the bromo intermediate in the presence of a base, optionally a phase transfer catalyst, a 1,2,4-triazole and an organic solvent to obtain anastrozole; and e) isolating and purifying the anastrozole from an organic solvent.

REFERENCES:
patent: 4935437 (1990-06-01), Edwards et al.
patent: RE36617 (2000-03-01), Edwards et al.
patent: 7692025 (2010-04-01), Villa et al.
patent: 2006/0035950 (2006-02-01), Alnabari et al.
patent: 2006/0189670 (2006-08-01), Khile et al.
patent: 1705168 (2006-09-01), None
patent: 2006108155 (2006-10-01), None
patent: 2007105231 (2007-09-01), None
patent: 2008047104 (2008-04-01), None
Foreign communication from the priority application—International Search Report and Written Opinion, PCT/GB2007/003942, Jan. 31, 2008, 12 pages.
Foreign communication from the priority application—International Preliminary Report on Patentability, PCT/GB2007/003942, Apr. 22, 2009, 6 pages.

Affiliated with

Also associated with

Rating

Process for the preparation of pure anastrozole does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of pure anastrozole, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of pure anastrozole will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2662265