Process for the preparation of pure 4,6-dihloropyrimidine

Details Process for the preparation of pure 4,6-dihloropyrimidine Process for the preparation of pure 4,6-dihloropyrimidine

1996-06-03

1998-03-03

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23902

Patent

active

057236127

ABSTRACT:
Process for the preparation of pure 4,6-dichloropyrimidine by reaction of 4,6-dihydroxypyrimidine with an excess of phosphorus oxychloride at 20.degree. C. up to reflux temperature, in the presence of a trialkylamine as acid scavenger and catalyst.

REFERENCES:
patent: 5525724 (1996-06-01), Hunds
patent: 5563270 (1996-10-01), Schwarz et al.
I. Wempen et al., J. Org. Chem., 6, 688-691 (1963).
B. Feit et al., J. Heterocycl. Chem., 11, 295-297 (1974).
G. Kenner et al., J. Chem. Soc., 574-575 (1943).

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