Process for the preparation of pure 1-phenyl-3-carbalkoxy-5-hydr

Details Process for the preparation of pure 1-phenyl-3-carbalkoxy-5-hydr Process for the preparation of pure 1-phenyl-3-carbalkoxy-5-hydr

1988-04-04

1989-06-06

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23122

Patent

active

048373354

ABSTRACT:
Process for the preparation of pure 1-phenyl-3-carbalkoxy-5-hydroxypyrazoles of the general formula ##STR1## in which R denotes methyl or ethyl, by reaction of acetylsuccinic esters with phenyldiazonium chloride and a base with pK.sub.B value of 3.6 to -1.5 at a pH of 4 to 9 in an aqueous medium to give the corresponding phenylhydrazone, which is cyclized at a pH of 7 to 9.5, with warming and with the addition of ammonia, to give the ammonium salt of the hydroxypyrazole. Compound I is formed by acidification.

REFERENCES:
patent: 2457823 (1949-01-01), Kendall et al.

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