Process for the preparation of pseudomonic acid a antibiotic...

Details Process for the preparation of pseudomonic acid a antibiotic... Process for the preparation of pseudomonic acid a antibiotic...

2006-07-18

2006-07-18

Marx, Irene (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S125000

Reexamination Certificate

active

07078223

ABSTRACT:
A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of aPseudomonasbacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of thePseudomonassp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20° C. and 30° C. containing organic nitrogen and carbon sources and, optionally, mineral salts.

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