Coating processes – Medical or dental purpose product; parts; subcombinations;... – Implantable permanent prosthesis
Reexamination Certificate
2008-07-18
2011-10-18
Szekely, Peter (Department: 1761)
Coating processes
Medical or dental purpose product; parts; subcombinations;...
Implantable permanent prosthesis
C427S318000, C427S338000, C427S435000
Reexamination Certificate
active
08039038
ABSTRACT:
This invention provides a process for the preparation of protein mediated calcium hydroxyapatite (HAp) coating on metal substrates particularly on stainless steel (316 L) by biomimetic route, capable of rapid and effective osteointegration with the host tissue following controlled interfacial reactions. For the purpose, calcium deficient, carbonated hydroxyapatite (HAp) coating was developed on metal substrates particularly on stainless steel (316L) alloy through biomimetic route after a surface treatment step using aqueous solution (4-10 wt %) of BSA at room temperature. The coating was characterized with respect to phase composition, crystallinity, morphology and thickness. The protein mediated calcium phosphate ceramic coating is porous (pore dia—100-200 μm) having uniform pore distribution and coverage. There is multifold enhancement in thickness and crystallinity (data provided) of the as-prepared coating. The process in the present invention is designed to mimic the structural and characteristic properties of the biological apatite to expedite osteointegration kinetics and to further improve biocompatibility of the metallic implant.
REFERENCES:
patent: 2003/0113438 (2003-06-01), Liu et al.
patent: 2007/0187857 (2007-08-01), Riley et al.
Debabrata Basu
Jui Chakraborty
Kumar Sinha Mithlesh
Sanghamitra Bharati
Council of Scientific and Industrial Research
Ladas & Parry LLP
Szekely Peter
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