Process for the preparation of protected phosphine oxides

Details Process for the preparation of protected phosphine oxides Process for the preparation of protected phosphine oxides

1993-03-23

1994-03-29

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus containing

568 15, 556405, C07F 953

Patent

active

052986632

ABSTRACT:
A process for the preparation of a protected phosphine oxide which comprises reacting a phosphinate ester having a protecting group on the phosphorus atom with an organomagnesium halide or an organolithium compound at a temperature of -70.degree. C. to 65.degree. C. Protected phosphine oxides so prepared are useful intermediates for the preparation of tertiary phosphine oxides and acylphosphine oxide photoinitiators.

REFERENCES:
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patent: 4933478 (1990-06-01), Wardleworth et al.
S. A. Buckler et al., Tetrahedron 18, 1211 (1962).
T. L. Emmick et al., J. Am. Chem. Soc., 90, 3459 (1968).
R. L. Wife et al., Synthesis 1983, 71-73, "Phosphine oxide anions in the Synthesis of Phosphine Ligands".
M. J. Gallagher et al., Aust. J. Chem. 33, 287 (1980).
Derwent Abst. 91-052929/08, 1991.
T. A. M. Van Schaik et al., Tetrahedron Letters 24, 1303 (1983).
Chem. Absts. 113, 52233z (1990).

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