Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Reexamination Certificate
2006-05-23
2006-05-23
Campell, Bruce R. (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
C530S337000, C530S336000, C530S335000, C530S300000, C530S350000, C530S344000
Reexamination Certificate
active
07049399
ABSTRACT:
A process for the preparation of a polypeptide designated in the present invention as 1, composed of the following amino acid units in the structure, namely: L-alanine, L-glutamic acid, L-lysine and L-tyrosine randomly arranged in the polypeptide 1, or pharmaceutically acceptable salts thereof, comprising the steps of:(a) polymerization of a mixture of the N-carboxyanhydrides of L-alanine, L-tyrosine, a protected L-glutamate and a protected L-lysine to obtain protected copolymer 6 or salt thereof;(b) deprotection of the protected copolymer 6 (or salt thereof) to produce polypeptide 1 or a pharmaceutically acceptable salt thereof in one single step;(c) separation and purification of the polypeptide 1 (or a pharmaceutically acceptable salt) to obtain a purified polypeptide 1
REFERENCES:
patent: 3849550 (1974-11-01), Teitelbaum et al.
patent: 5800808 (1998-09-01), Konfino et al.
patent: 5981589 (1999-11-01), Konfino et al.
patent: 6048898 (2000-04-01), Konfino et al.
patent: 6054430 (2000-04-01), Konfino et al.
patent: WO 95/31990 (1995-11-01), None
patent: WO 00/27417 (2000-05-01), None
Teitelbaum, D. et al., “Suppression of Experimental Allergic Encephalomyelitis by a Synthetic Polypeptide”,Eur. J. Immunol.,(1971), 1:242-248.
Bejan Elena
Horne Stephen E.
Weeratunga Gamini
Apotex Pharmachem Inc.
Campell Bruce R.
Hughes Ivor M.
Kosar Andrew D.
Sarkis Marcelo K.
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