Process for the preparation of polyamino acids

Details Process for the preparation of polyamino acids Process for the preparation of polyamino acids

2008-01-08

2008-01-08

Boykin, Terressa (Department: 1711)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From carboxylic acid or derivative thereof

C424S043000, C424S045000, C424S046000, C514S772100, C548S530000

Reexamination Certificate

active

07317070

ABSTRACT:
Among the various aspects of the present invention is an improved process for the preparation of polyamino acids generally, and more specifically, polyglutamic acid and polyaspartic acid. Another aspect is a process for the large scale (i.e. >1 kg) preparation of polyamino acids; particularly polyglutamic and polyaspartic acid.

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Weiwei Tian et al. , The Journal of Macromol Chem., 196, 3891-3903 (1995) Poly(L-lactic acid)—OCH2 CH2 CH2—NH2 and synthesis thereof as a initiator for the polymerization of N-carboxyanhydrides in the synthesis of poly(L-lactide)-block-poly(.alpha.-amino acid)s.
Goodman et al., “α-Amino Acid N-Carboxyanhydride Polymerizations—A Mechanistic Analysis”, Pure and Applied Chemistry, vol. 53, 1981, p. 699-714.

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