Process for the preparation of physiologically degradable, collo

Details Process for the preparation of physiologically degradable, collo Process for the preparation of physiologically degradable, collo

1981-12-30

1983-10-18

Hunt, Brooks H.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

252311, 252316, 252301R, 252302, 128650, 260112B, 260112R, A61K 4300, A61K 4900

Patent

active

044105070

ABSTRACT:
A colloidal solution of human serum albumin is prepared by mixing an aqueous solution of the latter with a non-ionic surface-active agent and an acid solution of a tin(II) salt, adjusting the pH to 3.5 to 8.0 and heating at a constant temperature between 45.degree. and 100.degree. C. until complete hydrolysis of the tin(II) salt and denaturation of the albumin have taken place; the colloidal solution can also be lyophilized. By treating the solution or the lyophilizate with a .sup.99m Tc-pertechnetate solution, a colloidal preparation is obtained for scintigraphy of the reticuloendothelial system or the lymphatic system. By suitable pH adjustment, the process makes it possible selectively to obtain colloids with a particle size of, for example, 3.0-0.2 or 0.2-0.03 or below 0.03 .mu.m.

REFERENCES:
patent: Re29066 (1976-12-01), Evans
patent: 3803299 (1974-04-01), Nonel
patent: 3863004 (1975-01-01), Wolfangel
patent: 3872226 (1975-03-01), Haney et al.
patent: 4024233 (1977-05-01), Winchell et al.
patent: 4042677 (1977-08-01), Molinski et al.
patent: 4094965 (1978-06-01), Layne et al.
patent: 4187285 (1980-02-01), Meeks et al.
patent: 4226846 (1980-10-01), Saklad
patent: 4293537 (1981-10-01), Wong
patent: 4305922 (1981-12-01), Rhodes

Affiliated with

Also associated with

Rating

Process for the preparation of physiologically degradable, collo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of physiologically degradable, collo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of physiologically degradable, collo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1289139