Process for the preparation of phenylalanine n-propyl ester hydr

Details Process for the preparation of phenylalanine n-propyl ester hydr Process for the preparation of phenylalanine n-propyl ester hydr

1988-10-11

1990-02-06

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C10110

Patent

active

048989665

ABSTRACT:
In order to prepare phenylalanine n-propyl ester hydrochloride, phenylalanine hydrochloride is reacted with n-propanol in the molar ration 1: (5 to 20) at temperatures from 80.degree. to 110.degree. C., preferably 85.degree. to 105.degree. C., at pressures from 0.1 to 1.5 bar in the presence of 0.1 to 0.75 mole of HCl/mole of phenylalanine hydrochloride as catalyst and in the presence of water entrainer, a concentration of water entrainer of 20 to 50% by weight being maintained in the reaction mixture.

REFERENCES:
patent: 3941831 (1976-03-01), Sollman
patent: 3983162 (1976-09-01), Schlatter
patent: 4680403 (1987-07-01), Hisamitsu et al.
"Mass-Transfer Operations", Robert E. Treytbal, McGraw-Hill Book company, Inc., 1955, pp. 344-347.
"Design of Equilibrium Stage Processes", William L. Bolles, McGraw-Hill Book Company, Inc., 1963, pp. 398-399 and 440-441.
Beilsteins Handbuch der Organischen Chemie, 4th Edition, vol. 14, Part 3, Beilstein-Institut, Springer-Verlag Berlin, 1985, pp. 1556-1557.

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