Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-10-04
2005-10-04
Aulakh, Charanjit S. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S304000, C549S331000, C560S021000, C562S457000
Reexamination Certificate
active
06951943
ABSTRACT:
A process for the preparation of a class of phenylalanine enamide derivatives is described:wherein:Ar1is an optionally substituted aromatic or heteroaromatic group; L2is a linker group selected from —N(R4)— [where R4is a hydrogen atom or an optionally substituted straight or branched C1-6alkyl group], —CON(R4)—, or —S(O)2N(R4)—;R1is a carboxylic acid (—CO2H) or a derivative or biostere thereof; R2is a hydrogen atom or a C1-6alkyl group; Rx, Ryand Rzwhich may be the same or different is each an atom or group -L1(Alk1)n(R3)v;and the salts, solvates, hydrates and N-oxides thereof;which comprises reacting a compound of formula (2):wherein:Qais a group —N(R4)H;and the salts, solvates, hydrates and N-oxides thereof;with a compound Ar1W wherein W is a group selected from X1(wherein X1is a leaving atom or group), —COX2(wherein X2is a halogen atom or a —OH group) or —SO2X3(in which X3is a halogen atom).
REFERENCES:
patent: WO 02/068393 (2002-09-01), None
Dunn, A.D., “The reaction of some brominated aminopicolines with acetic anhydride and with copper(I) cyanide,”J. Prakt. Chem., 1996, 338, 663-666.
Fieser, et al., Reagents for Organic Synthesis,John Wiley&Sons, 1999, vols. 1-19.
Katritzky (Ed.), Comprehensive Heterocyclic Chemistry,Pergamon, 1984, vols. 1-8.
Katritzky (Ed.), Comprehensive Heterocyclic Chemistry,Pergamon, 1994, vols. 1-11.
Katritzky, (Ed.), Comprehensive Organic Functional Group Transformations,Pergamon, 1995, vols. 1-7.
Larocks's comprehensive Organic Transformations,VCH Publishers, Inc., 1989.
March's Advanced Organic Chemistry,John Wiley&Sons, 1992.
Paquette (Ed.), Encyclopedia of Reagents for Organic Synthesis,John Wiley&Sons, 1995, vols. 1-8.
Rodd's Chemistry of Carbon Compounds,Elsevier Science Publishers, 1989, vols. 1-15.
Trost, et al. (Eds.), Comprehensive Organic Synthesis,Pergamon, 1991, vols. 1-9.
Wasserman, H.H., et al., “Cyclobutenone derivatives from ethoxyacetylene,”J. Org. Chem., 1973, 38(8), 1451-1455.
Brookes Michael Handforth
Jones Stephen Wilfred
Skead Benjamin Mark
Tyrrell Nicholas David
Aulakh Charanjit S.
Celltech R & D Limited
Woodcock & Washburn LLP
LandOfFree
Process for the preparation of phenylalanine enamide... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the preparation of phenylalanine enamide..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of phenylalanine enamide... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3461466