Process for the preparation of perdeuterated methacrylates

Details Process for the preparation of perdeuterated methacrylates Process for the preparation of perdeuterated methacrylates

1985-04-15

1987-02-24

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

556417, 5263297, 428394, 350 9634, 560205, C07C 6700

Patent

active

046458565

ABSTRACT:
Perdeuterated methacrylates of a high degree of deuteration can be obtained by a process for the preparation of perdeuterated methacrylates from hexadeuteroacetone by conversion into the corresponding cyanohydrin, subsequent elimination of water, hydrolysis of the cyano group and esterification with perdeuterated alkanols, the conversion of hexadeuteroacetone into the cyanohydrin being effected by reaction with trimethylsilyl cyanide to give 1,3-hexadeutero-2-(trimethylsiloxy)-2-cyano-propane and subsequent hydrolytic elimination of the trimethylsilyl group.

REFERENCES:
patent: 3419601 (1968-12-01), Isbell, Jr.
patent: 3466320 (1969-09-01), Hargis
patent: 4138194 (1979-02-01), Beasley et al.
patent: 4529816 (1985-07-01), DeColibus et al.
Fieser, et al., Reagents for Organic Synthesis, vol. 10, (1982), p. 3, John Wiley & Sons, N.Y.

Affiliated with

Also associated with

Rating

Process for the preparation of perdeuterated methacrylates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of perdeuterated methacrylates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of perdeuterated methacrylates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-109768