Process for the preparation of penicillin derivatives

Details Process for the preparation of penicillin derivatives Process for the preparation of penicillin derivatives

1980-05-13

1982-08-31

Trousof, Natalie

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-4-aza-bicyclo

2602391, C12P 3700

Patent

active

043473148

ABSTRACT:
A process for the preparation of .alpha.-carboxy, 6, .alpha.-methoxy penicillin derivatives by the enzymatic hydrolysis of an esterified derivative.
The process is for the preparation of a compound of formula (I): ##STR1## wherein R represents phenyl or 2- or 3-thienyl, which process comprises subjecting a compound of formula (IV): ##STR2## where R.sup.1 is an aryl radical, to the action of an enzyme selected from bromelain, papain, gelatase, trypsin, pancreatin or an esterase-producing strain of Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger or Saccharomyces sp.

REFERENCES:
patent: 3528965 (1970-09-01), Cole et al.

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