Process for the preparation of penicillanic acid 1,1-dioxides

Details Process for the preparation of penicillanic acid 1,1-dioxides Process for the preparation of penicillanic acid 1,1-dioxides

1983-04-19

1985-07-09

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602452T, C07D49900

Patent

active

045281351

ABSTRACT:
A process for the preparation of penicillanic acid-1,1-dioxides of the formula ##STR1## wherein X is selected from the group consisting of hydrogen and substituent such as halogen or acetoxy and R is selected from the group consisting of hydrogen, a pharmaceutically acceptable metal ion and/or ester radical comprising debrominating a 6-.alpha.-bromo- and/or 6,6-dibromo-penicillanic 1,1-dioxide selected from the group consisting of the formula ##STR2## wherein X and R have the above definition in an aqueous containing medium with zinc in association with an acid having a pK.sub.a -value measured in water less than 3.5 and optionally if R is H converting the acid into a pharmaceutically acceptable salt or ester.

REFERENCES:
patent: 4164497 (1979-08-01), Kamiya et al.
patent: 4419284 (1983-12-01), Crawford et al.
patent: 4444687 (1984-04-01), Gottstein

Affiliated with

Also associated with

Rating

Process for the preparation of penicillanic acid 1,1-dioxides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of penicillanic acid 1,1-dioxides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of penicillanic acid 1,1-dioxides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-908500