Process for the preparation of penems

Details Process for the preparation of penems Process for the preparation of penems

1984-08-06

1986-12-23

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540357, 514210, 514193, 514195, C07D49900, A61K 31425

Patent

active

046311505

ABSTRACT:
A process for preparing 2-methyl substituted penems useful as antibiotics agent and/or as intermediates thereof, by reacting an appropriate 1-imido-3,4-disubstituted azetidinone derivative with a trivalent organophosphorus compound in an inert solvent at a temperature of from 110.degree. to 150.degree. C. for a period of from 2 hours to a few days.

REFERENCES:
patent: 4443373 (1984-04-01), Girijavallabhan et al.
patent: 4500457 (1985-02-01), Gosteli et al.
patent: 4584133 (1986-04-01), Girijavallabhan

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