Process for the preparation of para-substituted derivatives of a

Details Process for the preparation of para-substituted derivatives of a Process for the preparation of para-substituted derivatives of a

1977-04-25

1979-03-06

Myers, Jane S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

260566A, 260599, 568592, C07C 6352

Patent

active

041432290

ABSTRACT:
Pharmacologically useful alpha (para-alkylphenyl) propionic acids having anti-inflammatory, analgesic and antipyretic activity are prepared from the corresponding 1-haloethyl-para-alkylbenzene by converting same to a diethylacetal via a Grignard reaction, followed by the conversion of said acetal to the corresponding aldehyde by hydrolytic means, converting the said aldehyde to an oxime derivative and hydrolyzing the latter to the desired acid.

REFERENCES:
patent: 3457300 (1969-07-01), Dorn et al.
patent: 3825572 (1974-07-01), VAN Venrooy et al.
patent: 3965161 (1976-06-01), Kogure et al.
patent: 4052194 (1977-10-01), Wilcox
Heldt et al., Organic Reactions II, pp. 1-156 (1960).
Patai, The Chemistry of the Carbon-Nitrogen Double Bond, pp. 408-439 (1970).
Jordan et al., J.A.C.S. 58, pp. 1304-1305 (1936).
Fieser et al., Reagents for Organic Synthesis, vol. I, pp. 479, 1204, 1205 (1967).
Brewster et al., Organic Chemistry, Third Edition, pp. 760-761 and 179, (1964).

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