Process for the preparation of optionally substituted 1,2,3,5-te

Details Process for the preparation of optionally substituted 1,2,3,5-te Process for the preparation of optionally substituted 1,2,3,5-te

1974-11-06

1976-09-28

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602565R, 424251, C07D18704

Patent

active

039831191

ABSTRACT:
A new process has been developed for the synthesis of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones. In particular, the process is particularly adaptable for the preparation of the 5,6-disubstituted compounds, e.g., 5,6-dimethyl-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolin-2-one. The compounds so prepared are useful as blood platelet anti-aggregative and/or antihypertensive agents in mammals, including humans.

REFERENCES:
patent: 3257401 (1966-06-01), Wagner
patent: 3600390 (1971-08-01), Sherlock
patent: 3621025 (1971-11-01), Jen et al.
patent: 3745216 (1973-07-01), Jen et al.
patent: 3790576 (1974-02-01), DeWald
patent: 3859289 (1975-01-01), Hardtmann
Bernard, et al., "Chemical Abstracts," vol. 74, 1971, Col. 1418596.
Brown, Heterocyclic Compounds: Fused Pyrimidines, Part I, 1967, Wiley-Interscience, N.Y. pp. 222-225.
Cox, et al., "J. Chem. Soc. (c), 1970, pp. 2134-2136.
Beverung, et al., J. Med. Chem., vol. 18, 1975, pp. 224-225.

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