Process for the preparation of optically pure isomers of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Reexamination Certificate

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Reexamination Certificate

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11247490

ABSTRACT:
The invention provides a process for preparing R-(+)-2-(4-hydroxyphenoxy)-2-methyl-butyric acid methyl ester of the formula (I):Various embodiments and variants are provided.The invention also provides a process for preparing S-(−)-2-(4-hydroxyphenoxy)-2-methyl-butyric acid methyl ester of the formula (II)Various embodiments and variants are provided.

REFERENCES:
Shi, Yao-Jun; Hughes, David L.; McNamara, James M Stereospecific synthesis of chiral tertiary alkylaryl ethers via Mitsunobu reaction with complete inversion of configuration. Tetrahedron Letters (2003), 44(18), 3609-3611.

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