Process for the preparation of optically pure amides

Details Process for the preparation of optically pure amides Process for the preparation of optically pure amides

1990-09-24

1992-02-04

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544105, 546 79, 546 80, 546 81, 546 83, 546 89, 546 90, 546101, 546110, 546111, 546 93, 546103, 546104, 546107, 546195, 546196, 546197, 546202, 564123, 564172, 564192, C07D45302, C07B 5300, C07C23108

Patent

active

050861794

ABSTRACT:
This invention is directed to certain dibenzofurancarboxamides and dibenzofurancarboxamide acids and their use as 5HT.sub.3 antagonists having unique CNS, anti-emetic and gastric prokinetic activity void of any significant D.sub.2 receptor binding properties. Further, this invention relates to a process for the synthesis of stereoisomeric compounds having such CNS, anti-emetic and gastric prokinetic activity.

REFERENCES:
patent: 4863921 (1987-09-01), Youssefyeh et al.
Sidgwich, The Organic Chemistry of Nitrogen, Oxford Univ. Press, London (1945) pp. 144-145.
McOmie, Protective Groups in Organic Chemistry, Plenum Press, London N. York (1973) p. 408.
Zabicky, The Chemistry of Amides, Interscience, New York, N.Y., pp. 830, 831 & 855 (1970).
Cohen et al., J. Am. Chem. Soc., vol. 86, pp. 5611-5616 (1964).
Lacey, J. Chem. Soc., pp. 1633-1639 (1960).

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