Process for the preparation of optically active piperazine-2-car

Details Process for the preparation of optically active piperazine-2-car Process for the preparation of optically active piperazine-2-car

1996-05-23

1999-03-23

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544387, 544389, 544390, 544121, C07D24104, C07D41306

Patent

active

058861815

ABSTRACT:
Optically active piperazine-2-carboxylic acid derivatives of the general formula: ##STR1## wherein R.sup.1 and R.sup.2 are inter alia hydrogen, alkyl or acyl and X is alkoxy or a (substituted) amino group, are prepared by asymmetric hydrogenation of the corresponding 1,4,5,6-tetrahydropyrazines, catalyzed by optically active rhodium, ruthenium or iridium complexes. The compounds of the Formula 1 are intermediates for the preparation of pharmaceutical active ingredients, for example, HIV protease inhibitors.

REFERENCES:
patent: 5011995 (1991-04-01), Pugin et al.
patent: 5371256 (1994-12-01), Togni et al.
patent: 5463067 (1995-10-01), Askin et al.
patent: 5463097 (1995-10-01), Togni et al.
patent: 5466844 (1995-11-01), Spindler et al.
patent: 5491238 (1996-02-01), Askin et al.
patent: 5496948 (1996-03-01), Askin et al.
patent: 5563308 (1996-10-01), Spindler et al.
patent: 5563309 (1996-10-01), Togni et al.
patent: 5565594 (1996-10-01), Spindler et al.
patent: 5583241 (1996-12-01), Spindler
patent: 5618939 (1997-04-01), Askin et al.
patent: 5637711 (1997-06-01), Askin et al.
patent: 5723615 (1998-03-01), Rossen et al.
Rossen et al, Tetrahedron Letters 36, pp. 6419-6422 (Sep. 4, 1995).
Kandzia et al, Chemical Abstracts, vol. 125, No. 142774 (1996) (Abstract for DE 4,446,025 Jun. 27, 1996). 1989), Yasuo et al.
E. Felder et al., "Uber die katalytische . . . ", Helv. Chim. Acta, vol. 43, (1960), pp. 888-896.
T. Hayashi et al., "Optically Active Ruthenocenylbis(phosphines) . . . ", J. Am. Chem. Soc., (1994), 116, 4221-4226.
T. Hayashi et al., "Asymmetric Synthesis . . . ", Bull. Chem. Soc. Jpn., (1980), 53, 1138-1151.
J.C. Sheehan et al., J. AM. Chem. Soc., (1958), 80, 1154.

Affiliated with

Also associated with

Rating

Process for the preparation of optically active piperazine-2-car does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of optically active piperazine-2-car, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of optically active piperazine-2-car will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2127041