Process for the preparation of optically active nicotine analogs

Details Process for the preparation of optically active nicotine analogs Process for the preparation of optically active nicotine analogs

1980-03-21

1982-03-23

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546282, 2603265R, 424264, C07D40104, C07D20712

Patent

active

043213871

ABSTRACT:
A method is disclosed for preparing chiral nicotine and nicotine analogues of the formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are hydrogen or alkyl and R.sub.4 is alkyl. Also disclosed are novel intermediate compounds and a novel method for preparing 1-methylprolinol from prolinol, which compounds and method are useful for the preparation of these nicotinoids.

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