Process for the preparation of optically active .alpha.-phenylgl

Details Process for the preparation of optically active .alpha.-phenylgl Process for the preparation of optically active .alpha.-phenylgl

1976-03-25

1978-09-19

Thomas, Jr., James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

26050112, C07C10104, C07C14326

Patent

active

041154398

ABSTRACT:
DL- .alpha.-phenylglycine can be combined with benzene-sulfonic acid, p-ethylbenzenesulfonic acid or m-xylenesulfonic acid to give the salt. The salt of the racemate may be more soluble in a sulfuric acid solution than the salt of the optically active isomer by suitably choosing the concentration of the sulfuric acid solution, and then the optical resolution by fractional crystallization is carried out. The D- or L- .alpha.-phenylglycine sulfonate is easily liberated of the sulfonic acid portion to give optically active D- or L- .alpha.-phenylglycine.

REFERENCES:
patent: B544899 (1976-02-17), Shirai
patent: 3933902 (1976-01-01), Watanabe et al.
Nagai et al., Chem. Abstracts, vol. 78, 16478(h) (1973).

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