Process for the preparation of optically active a-hydroxycarboxy

Details Process for the preparation of optically active a-hydroxycarboxy Process for the preparation of optically active a-hydroxycarboxy

1992-12-10

1993-11-16

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

548216, 548239, C07C 5940, C07D26352

Patent

active

052625664

ABSTRACT:
The invention relates to a process for the preparation of optically active .alpha.-hydroxycarboxylic acids characterised in that carbamates are first reacted in the presence of a selective base and of a chelate-forming diamine to give a carbanion complex compound, this is then dia- or enantioselectively deprotonated, then substituted with CO.sub.2 and, as a final step, the heterocyclic protective group is eliminated.

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