Process for the preparation of optically active...

Details Process for the preparation of optically active... Process for the preparation of optically active...

2007-04-17

2007-04-17

Solola, Taofiq (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10500023

ABSTRACT:
The present invention relates to new process for preparing as a key chiral intermediate compound of formula (I) obtained from an epoxy-β-hydroxy carboxylic acid ester of formula (II) prepared from epoxide compound of formula (III), in which said compound of formula (I) is useful for preparing the therapeutic agent for hyperlipidemia, such as Astrovastatin and Fluvastatin. Wherein R1denotes a hydrogen atom, alkyl, aryl or alkylaryl, R2and R3which can be identical or different, are a lower alkyl or phenyl and are capable of forming a six-membered ring, R4stands for hydroxy, amino, alkylamino, azido, cyano, halogeno, aryloxy, alkyloxy, arylalkyloxy, alkyl, alkenyl, aryl, or aminomethyl, etc.

REFERENCES:
patent: 5155251 (1992-10-01), Butler et al.
patent: 5278313 (1994-01-01), Thottathil et al.

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