Process for the preparation of optically active...

Details Process for the preparation of optically active... Process for the preparation of optically active...

2006-10-03

2006-10-03

Marx, Irene (Department: 1651)

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C435S108000, C435S170000, C435S171000, C435S169000

Reexamination Certificate

active

07115412

ABSTRACT:
Disclosed are a process for preparation of an optically active 7-substituted 3-(2-aminopropyl)indole compound and an intermediate therefor. In the above preparation process, 7-substituted indole is reacted with L- or DL-serine in the presence of a tryptophan-synthesizing enzyme originating in microorganisms to form corresponding 7-substituted L-tryptophan, and it is subjected, if necessary, to reduction, protection, exchange and elimination.

REFERENCES:
Eich et al., Herba Hungarica (1968), 7(2-3), 91-103.
Brewster et al., “Organic Chemistry” 3rd Edition, Prentice Hall, Inc. 1961, pp. 219-220.
K. Helen Ekborg Ott, et al., “Highly Enantioselective HPLC Separations Using the Covalently Bonded Macrocyclic Antibiotic, Ristocetin A, Chiral Stationary Phase”, Chirality, vol. 10, No. 5, pp. 434 to 483, 1998.
Jhon C. Gebler et al., “Dimethylallyltryptophan Synthase. An Enzyme-Catalyzed Electrophilic Aromatic Substitution”, J. Am. Chem. Soc., vol. 114, No. 19, pp. 7354-7360, 1992.
E.M.M. Van Den Berg et al., “Chemo-enzymic synthesis and characterization of L-tryptophan selectively 13C-enriched or hydroxylated in the six-membered ring using transformedEscherichia colicells”, Recueil Des Travaux Chimiques Des Pays-Bas, 109(4), pp. 287-297, XP002082902, 1990.

Affiliated with

Also associated with

Rating

Process for the preparation of optically active... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of optically active..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of optically active... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3641689