Process for the preparation of optically active 2-halo-1-(substi

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

558415, 558418, 558420, 558425, 558423, 562493, 564400, 564401, 564404, 568725, C07C20902, C07C 3320, C07C 3334

Patent

active

058410015

ABSTRACT:
The present invention provides an industrially advantageous process for the preparation of an optically active 2-halo-1-(substituted phenyl)ethanol useful as medicines, agricultural chemicals or as intermediates thereof; and a simple process for the preparation of an optically active substituted styrene oxide or 2-amino-1-(substituted phenyl)ethanol useful as medicines, agricultural chemicals or intermediates thereof. A 2-halo-1-(substituted phenyl)ethanol represented by the following general formula (I) is allowed to contact, in the presence of a carboxylic anhydride, with an enzyme stereoselectively catalyzing ester interchange to produce an optically active 2-halo-1-(substituted phenyl)ethanol: ##STR1## (wherein X represents a chlorine atom or a bromine atom, and R.sup.1, R.sup.2 and R.sup.3 may be the same or different and each represent a hydrogen atom, a halogen atom, a C.sub.1-5 alkyl group, a C.sub.1-5 haloalkyl group, a C.sub.1-5 alkoxy group, a cyano group or a nitro group, with the proviso that when two of R.sup.1, R.sup.2 and R.sup.3 are alkyl groups or alkoxy groups, they may be combined together to form a ring and that all of R.sup.1, R.sup.2 and R.sup.3 are not hydrogen atoms at the same time).

REFERENCES:
Chemical Abstracts 116:40562, 1991.
Nieduzak, Tetrahedron: Asymmetry, vol 2(2), pp. 113-122, 1991.
Casreact #102: 184439, 1985.
Casreact #104: 168047, 1985.
Casreact #106: 18013, 1985.
Casreact #109:6342, 1988.
Casreact 117:131102, 1992.
Casreact #118:212177, 1993.
CASREACT 125:167489, 1996.
CHEMINFORMRX 199344084, 1993.
CHEMINFORMRX 199209060, 1992.
CHEMINFORMRX 199422086, 1994.
CHEMINFORMRX 199520038, 1995.
CHEMINFORMRX 199520059, 1995.
CHEMINFORMRX 199612182, 1996.
CASREACT 102: 184439, 1985.
CASREACT 103: 177665, 1985.
CASREACT 105:6658, 1985.
CASREACT 113:58884, 1989.
CASREACT 115:158610, 1991.
CASREACT 121:205392, 1994.
CASREACT 122: 160381, 1995.
CASREACT 122:291227, 1995.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process for the preparation of optically active 2-halo-1-(substi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of optically active 2-halo-1-(substi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of optically active 2-halo-1-(substi will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1704679

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.