Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Patent
1997-02-28
1998-11-24
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
558415, 558418, 558420, 558425, 558423, 562493, 564400, 564401, 564404, 568725, C07C20902, C07C 3320, C07C 3334
Patent
active
058410015
ABSTRACT:
The present invention provides an industrially advantageous process for the preparation of an optically active 2-halo-1-(substituted phenyl)ethanol useful as medicines, agricultural chemicals or as intermediates thereof; and a simple process for the preparation of an optically active substituted styrene oxide or 2-amino-1-(substituted phenyl)ethanol useful as medicines, agricultural chemicals or intermediates thereof. A 2-halo-1-(substituted phenyl)ethanol represented by the following general formula (I) is allowed to contact, in the presence of a carboxylic anhydride, with an enzyme stereoselectively catalyzing ester interchange to produce an optically active 2-halo-1-(substituted phenyl)ethanol: ##STR1## (wherein X represents a chlorine atom or a bromine atom, and R.sup.1, R.sup.2 and R.sup.3 may be the same or different and each represent a hydrogen atom, a halogen atom, a C.sub.1-5 alkyl group, a C.sub.1-5 haloalkyl group, a C.sub.1-5 alkoxy group, a cyano group or a nitro group, with the proviso that when two of R.sup.1, R.sup.2 and R.sup.3 are alkyl groups or alkoxy groups, they may be combined together to form a ring and that all of R.sup.1, R.sup.2 and R.sup.3 are not hydrogen atoms at the same time).
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Tanaka Ken
Ueda Makoto
Yasuda Mari
Kight John
M. Mach D. Margaret
Mitsubishi Chemical Corporation
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