Process for the preparation of optically active 2-arylpropionic

Details Process for the preparation of optically active 2-arylpropionic Process for the preparation of optically active 2-arylpropionic

1989-07-26

1992-02-18

Rosen, Sam

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435141, 435280, 514568, C12P 740

Patent

active

050894056

ABSTRACT:
S Enantiomers of 2-arylpropionic acids are made by enantioselective hydrolysis of the corresponding racemic 2-arylpropionamides in the presence of a microorganism, or of an enzyme derived therefrom, able selectively to hydrolyze racemic .alpha.-phenylpropionamide to S .alpha.-phenylpropionic acid. The S Enantiomers obtained may be incorporated into antiinflammatory, analgesic and antipyretic compositions.

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patent: 4366250 (1982-12-01), Jallageas et al.
patent: 4812403 (1989-03-01), Boesten et al.
Zbl. Bakt. Hyg., I. Abt. Orig. A220, 452-456 (a1972) Frommer et al.
Chemical Abstracts, vol. 91, 1979, p. 610.
25 Noncondensed Aromatics, vol. 83, 1975, pp. 471-472 (27810).
Chemical Abstracts, vol. 81, 1974, p. 376.
Thiery et al, Chem. Abst., vol. 105 (1986), p. 167, 595W.
Dotani et al, Chem. Abst., vol. 104 (1986), p. 166,912Q.

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