Process for the preparation of optically active...

Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...

Reexamination Certificate

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C435S120000

Reexamination Certificate

active

07993904

ABSTRACT:
A process for the production of an optically enriched oxazolidinone of the formula (2a) or (2b), by reacting an epoxide of the formula (1) with cyanate in the presence of halo-hydrin dehalogenase.

REFERENCES:
patent: 2003/0124693 (2003-07-01), Spelberg et al.
patent: WO-01/90397 (2001-11-01), None
patent: WO-2005/017141 (2005-02-01), None
Bertau, M., et al., “A Novel Highly Stereoselective Synthesis of Chiral 5- and 4,5-Substituted 2-Oxazolidinones”, Tetrahedron: Asymmetry, 2001, vol. 12, pp. 2103-2107.
Lutje Spelberg, J. H., et al., “Exploration of the Biocatalytic Potential of a Halohydrin Dehalogenase using Chromogenic Substrates”, Tetrahedron: Asymmetry, 2002, vol. 13, pp. 1083-1089.
Kasai, N., et al., “Chiral C3 Epoxides and Halohydrins: Their Preparation and Synthetic Application”, Journal of Molecular Catalysis B: Enzymatic, 1998, vol. 4, pp. 237-252.
Nakamura, T., et al., “A New Catalytic Function of Halohydrin Hydrogen-Halide-Lyase, Synthesis of β-Hydroxynitriles from Epoxides and Cyanide”, Biochemical and Biophysical Research Communications, 1991, vol. 180, No. 1, pp. 124-130.

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