Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1984-02-23
1986-12-16
Brown, Johnnie R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
536 21, 536123, 536 187, C12P 1904, C12P 1926, C07H 3700
Patent
active
046296999
ABSTRACT:
Process for the preparation of oligosaccharides and oligosaccharide fractions by degradation of heparin, which comprises submitting to incubation an aqueous solution of heparin containing from 5 to 30 g of heparin/liter in the presence of 4-50 m.moles/l of cupric acetate and 50-300 m.moles/l of hydrogen peroxide, at a temperature of 40.degree.-50.degree. C., for 20-24 hours and keeping the pH at a value of 7.8 by means of sodium acetate.
The obtained products show a high inhibiting property of the Xa factor, a high antithrombotic activity and a very modest anticoagulant activity; therefore they are very interesting for a possible utilization as drugs in the antithrombotic treatment, practically free from any risk of haemorrhages.
REFERENCES:
patent: 4281108 (1981-07-01), Fussi
patent: 4303651 (1981-12-01), Lindahl et al.
patent: 4351938 (1982-09-01), Barnett
patent: 4401662 (1983-08-01), Lormeau et al.
patent: 4474770 (1984-10-01), Lormeau et al.
patent: 4500519 (1985-02-01), Lormeau et al.
Brown Johnnie R.
Opocrin S.p.A.
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