Process for the preparation of O-substituted derivatives of (+)-

Details Process for the preparation of O-substituted derivatives of (+)- Process for the preparation of O-substituted derivatives of (+)-

1978-11-21

1981-03-10

Chan, Nicky

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424283, C07D31162

Patent

active

042553369

ABSTRACT:
The subject of the present invention is new O-substituted derivatives of (+)-cyanidan-3-ol corresponding to the general formula I ##STR1## in which R represents an optionally substituted hydrocarbon radical; an acyl radical of an organic carboxylic acid containing at least 2 carbon atoms, of a carbonic acid or of an organic sulphonic acid; or a radical of an inorganic acid containing at least one oxygen atom, with the exception of a glucosidic radical, and the salts thereof, a process for the preparation thereof as well as their application in therapeutics and medicaments containing these new products.
These compounds have a valuable activity in the prevention of hepatic necrosis and also inhibit lipoperoxidation. In addition, they are capable of acting on the fibrillation of collagen.

REFERENCES:
patent: 2861992 (1958-11-01), Chabrier de Lassauniere
patent: 3314975 (1967-04-01), Jurd et al.
patent: 3661890 (1972-05-01), Jurd et al.
Freudenberg et al., Chem. Ber., 55, 1737 (1922).
Weiges et al., Liebigs Ann. Chem., 714, 193 (1968).

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