Process for the preparation of nucleotides

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544229, 544243, C07D23947

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active

055918522

ABSTRACT:
The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.

REFERENCES:
patent: 4808716 (1989-02-01), Holy et al.
Bronson et al, "Synthesis and Antiviral Activity of the Nucleotide Analogue (S)-1-[3-Hydroxy-2-(phosphonylmethoxy)propyl]cystosine," J MED CHEM 32: 1457-1463 (1989).
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Holy et al, "Synthesis of (3-Hydroxy-2-Phosphonylmethoxypropyl) Derivatives of Heterocyclic Bases," Collect Czech Chem Commun 54:2470-2501 (1989).
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Holy, Antonin, "Syntheses of Enantiomeric N-(3-Hydroxy-2-Phosphonomethoxypropyl) Derivatives of Purine and Pyrimidine Bases," Collect Czech Chem Commun 58:649-674 (1993).
Kritsyn et al., "Nonglycoside Analogs of Nucleotides," KHIM. Geterotsikl. Soedin. 1:125-131 (Jan. 1975).
Mikhailov et al., "Non-Glycosidic Analogues of Nucleotides: 2'(R),3'(S),5'-Trihydroxypentyl Derivatives of Adenine and Cytosine," Tetrahedron 32:2409-2415 (1976).
Snoeck et al., "(S)-1-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine, a Potent and Selective Inhibitor of Human Cytomegalovirus Replication," Antimicro AG & Chemo 32(12):1839-1844 (Dec. 1988).
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