Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1992-01-21
1995-12-19
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544244, C07F 938, C07F 940, C07B 4300
Patent
active
054769388
ABSTRACT:
The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.
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Stevens, J Het Chem 20, 295 (1983).
Ueda, J Het Chem 8, 827 (1971).
Sata, Bull Chem Soc Japan 46, 1572 (1973).
Webb, Nucleosides & Nucleotides 8, 619 (1989).
Terry, Antiviral Res 10, 235-252 (1988).
Rosenberg, Coll. Czech Chem. Comm 53, 2753 (1988).
Robert M. Hanson, "The Synthetic Methodology of Nonracemic Glycidol and Related 2,3-Epoxy Alcohols", Chemical Reviews, vol. 91, No. 4, (Jun. 1991) pp. 437-475.
Brodfuehrer Paul R.
Howell Henry G.
Sapino, Jr. Chester
Vemishetti Purushortham
Berch Mark L.
Hensley Max D.
Institute of Organic Chemistry and Biochemistry of the Academy o
Rega Stichting v.z.w.
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