Process for the preparation of nucleoside alkyl-aralkyl- and ary

Details Process for the preparation of nucleoside alkyl-aralkyl- and ary Process for the preparation of nucleoside alkyl-aralkyl- and ary

1987-12-28

1992-11-24

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 2104, C07H 1700, C07H 1910, C07H 1920

Patent

active

051663309

ABSTRACT:
Deoxyribonucleoside phosphonates, thiophosphonates and selenophosphonates are obtained by condensation of a difunctional phosphonylating reagent of the formula

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patent: 4973679 (1990-11-01), Caruthers et al.
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Sinha et al., A New Synthesis of Oligodeoxynucleoside Methylphosphonates on . . . Glass . . . Support Using Phosphite Approach, Tetrahedron Letters 24(9), 877-80 (1983).
Agarwal et al., Synthesis . . . of Deoxyribooligonucleotides Containing Methyl and Pherylphosphonate Linkages, Nucleic Acids Research 6(9), 3009-3024 (1979).
Nemer et al., Ribonucleotide Analogues Having Novel Internucleotide Linkages, Tetrahedron Letters 21, 4149-52 (1980).
Burgers et al., Synthesis of Dinucleoside Monophosphorothioates via Addition of Sulphur to Phosphite Triesters, Tetrahedron Letters 40, 3835-38 (1978).
Miller et al., Nonionic Nucleic Acid Analogues, Synthesis and Characterization of Dideoxyribonucleoside Methylphosphonates, Biochemistry 18(23) 5134-43 (1979).

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