Process for the preparation of nojirimycin and related compounds

Details Process for the preparation of nojirimycin and related compounds Process for the preparation of nojirimycin and related compounds

1990-11-14

1993-07-13

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 174, 536 179, 536 553, 536 54, 546219, 502339, C07H 100, B01J 2342, B01J 2100, C07D21140

Patent

active

052274799

ABSTRACT:
The present invention relates to an efficient new route for the preparation of (+)-nojirimycin and (+)-1-deoxynojirimycin which involves the stereoselective reductive amination of 1,2-O-isopropylidene-5-oxo-.alpha.-D-glucuronolactone. The reductive amination uses particular oximes of the 5-oxo compound.

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patent: 4908439 (1990-03-01), Anzeveno
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Reitz et al., Tetrahedron Letters, 31, 6777 (1990).
Morrison and Boyd, "Organic Chemistry" 3rd Edition, published 1982 by Allyn and Bacon, Inc. (Boston), see p. 640.

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