Process for the preparation of new organ transplants

Details Process for the preparation of new organ transplants Process for the preparation of new organ transplants

1982-07-01

1983-05-17

Tungol, Maria Parrish

Bleaching and dyeing; fluid treatment and chemical modification

Treatment of hides, skins, feathers and animal tissues

Internal tissues

8 9433, A01N 100, A61F 122

Patent

active

043838324

ABSTRACT:
The organ transplants are intended to be used as a replacement (prostheses) for organs or parts of organs, for examples arteries or veins, which have undergone pathological change or are functionally impaired. The organs, which are taken from a fish, bird or higher mammal, are subjected to crosslinking of the amino groups and of the alcoholic hydroxyl groups of the peptide chains of the intercellular matix by means of a di-, tri- or poly-carboxylic acid. It is advantageous subsequently to treat the crosslinked product with a dialdehyde, in order to bind amino groups which have not reacted, or to free the crosslinked product from material which potentially may act as an antigen, by hydrolysis with ficin, papain or a protease having a smaller action. After the hydrolysis, a comprehensive crosslinking is appropriately ensured using a dialdehyde or a di-, tri- or poly-carboxylic acid. The resulting prostheses are distinguished by chemical stability, biophysical and biochemical properties similar to those of the natural material and the absence of rejection reactions.

REFERENCES:
patent: 3093439 (1963-06-01), Bothwell
patent: 3166074 (1965-01-01), Kurilla
patent: 4082507 (1978-04-01), Sawyer
patent: 4120694 (1978-10-01), Schechter

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