Process for the preparation of naproxene nitroxyalkylesters

Details Process for the preparation of naproxene nitroxyalkylesters Process for the preparation of naproxene nitroxyalkylesters

2007-07-03

2007-07-03

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrate esters or chalcogen analogues thereof

C558S483000

Reexamination Certificate

active

10625558

ABSTRACT:
A process for obtaining nitroxyalklesters of the 2(S)(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess higher than or equal to 95%, preferably higher than or equal to 98%, characterized in that an halide of the 2-(S)-(6 methoxy-2-naphthyl)propanoic acid of formula A-Hal, wherein A is the acid acyl residue, is reacted in an inert organic solvent with an aliphatic nitroxyalkanol HO—Y—ONO2, wherein Y is a C2-C20alkylene or a cycloalkylene from 3 to 8 carbon atoms, or an alkylene as defined containing a cycloalkylene as defined, in the presence of an inorganic base.

REFERENCES:
patent: 5700947 (1997-12-01), Del Soldato
patent: 2 757 159 (1998-06-01), None
patent: WO 92/01668 (1992-02-01), None
patent: WO 95/09831 (1995-04-01), None
patent: WO 95/30641 (1995-11-01), None
patent: WO 97/16405 (1997-05-01), None
patent: WO 98/25918 (1998-06-01), None
DeLucchi et al.; Gazetta Chimica Italiana, 117, pp. 173-176 (1987), “Chemoselective Reduction of Isosorbide-2,5-Dinitrate”.

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