Process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro-

Details Process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro- Process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro-

1977-10-11

1979-11-13

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

2603478, C07D40504

Patent

active

041744462

ABSTRACT:
The present invention relates to a new process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro-uracil, also called Ftorafur, which is a very important anti-cancer compound. Said process comprises reacting 2,3-dihydrofuran with water in the presence of a catalytic amount of an acidic catalyst at a pH below 2.5, removing excess of unreacted starting materials and reacting the mixture obtained with silylated-5-fluoro-uracil is in the presence of a Friedel Crafts type catalyst uracil in an inert organic solvent. The new process has many advantages in comparison with those used so far.

REFERENCES:
patent: 3912734 (1975-10-01), Giller et al.

Affiliated with

Also associated with

Rating

Process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro- does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro-, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of N.sup.1 -(2'-furanidyl)-5-fluoro- will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2272639