Process for the preparation of N-substituted lactams

Details Process for the preparation of N-substituted lactams Process for the preparation of N-substituted lactams

1997-07-08

1999-11-16

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540533, 546243, 548952, 548543, C07D21174, C07D22310, C07D22708, C07D 4106

Patent

active

059860928

ABSTRACT:
The invention relates to a process for the preparation of N-substituted lactams by reaction of a lactam, which is unsubstituted on the nitrogen, with an organic halide in the presence of at least one solid-liquid phase transfer catalyst, such as a quaternary ammonium salt, and of at least one solid inorganic base, such as an alkali metal hydroxide, and in the absence of solvent. By this process, N-substituted lactams are obtained with good yields and high purity. The absence of solvent makes possible a considerable gain in productivity and an improvement in safety and in regard for the environment.

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Yang et al., Huaxue Shiji (1993), 15 (2), 81-82. (Abstract only), 1993.
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Yang et al., Zhongguo Yiyao Gongye Zazhi (1992), 23 (5), 195-7, 207. (Abstract only), 1992.
Heterocycles, vol. 12, No. 11, 1979, pp. 1449-1451, XP000646488.

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