Process for the preparation of N-benzyl-N-organoaminoalkanol

Details Process for the preparation of N-benzyl-N-organoaminoalkanol Process for the preparation of N-benzyl-N-organoaminoalkanol

1994-10-26

1995-07-25

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

560 42, 558422, C07C21300, C07C21302

Patent

active

054363730

ABSTRACT:
N-benzyl-N-organo-substituted aminoalkanol is prepared by reacting benzyl chloride or substituted benzyl chloride with an organo-substituted aminoalkanol in the presence of a molar excess of the starting aminoalkanol and, optionally, water, and in the absence of a) an organic solvent for the reactants and b) alkali metal hydroxide. A portion of the excess aminoalkanol may be substituted with an alternative amine or dissolved alkali metal carbonate.

REFERENCES:
patent: 2828320 (1958-03-01), Freifelder
patent: 2828328 (1958-03-01), Schmidt et al.
patent: 5002953 (1991-03-01), Hindley
Chemical Abstracts vol. 52, 11930-1 (1958).
Jour. Amer. Chemical Soc. 80 4320-3 (1958) "Local Anesthetics" Freifelder et al.
Encyclopedia of Chemical Tech., Kirk-Othmer Third Ed., vol. 19, pp. 521-531 (1982).

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