Process for the preparation of n-acetylphenylalanine

Details Process for the preparation of n-acetylphenylalanine Process for the preparation of n-acetylphenylalanine

1988-10-14

1990-01-09

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 9906

Patent

active

048929719

ABSTRACT:
In the process for the preparation of N-acetylphenylalanine by opening the ring of 2-methyl-4-benzylidene-1,3-oxazolin-5-one with water to give 2-acetaminocinnamic acid and subsequently catalytically hydrogenating the latter, both reaction stages are carried out in a mixture of an aliphatic C.sub.3 -ketone to C.sub.10 -ketone or a water-miscible ether and water as the solvent, and the hydrogenation of the 2-acetaminocinnamic acid is carried out at temperatures of 10.degree. to 50.degree. C. and pressures of 1 to 15 bar in the presence of a supported palladium catalyst.

REFERENCES:
patent: 2449191 (1948-09-01), Behrens
patent: 3574763 (1971-04-01), Wollner et al.
patent: 4508921 (1985-04-01), Amato et al.
patent: 4535167 (1985-08-01), Freidinger
patent: 4612388 (1986-09-01), Mita et al.
patent: 4613691 (1986-09-01), Mirviss et al.
patent: 4675439 (1987-06-01), Mita et al.

Affiliated with

Also associated with

Rating

Process for the preparation of n-acetylphenylalanine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of n-acetylphenylalanine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of n-acetylphenylalanine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-146325