Process for the preparation of morpholine and piperidine derivat

Details Process for the preparation of morpholine and piperidine derivat Process for the preparation of morpholine and piperidine derivat

1981-02-02

1983-05-17

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544106, 546192, C07D26530, C07D29502, C07D29506

Patent

active

043841163

ABSTRACT:
The invention relates to an improved process for the preparation of fungicidally active compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 individually are lower alkyl of from 1 to 4 carbons or halo-(lower alkyl) of from 1 to 4 carbons or R.sub.1 and R.sub.2 together with the carbon to which they are attached form a 3 to 7 membered cycloalkyl ring or lower alkyl-substituted cycloalkyl of from 4 to 9 carbons, R.sub.3, R.sub.4 and R.sub.5 individually are hydrogen or lower alkyl of from 1 to 4 carbons and X is methylene or oxygen, and salts of those compounds which are basic.
The improved process comprises the reaction of a compound of the formula, ##STR2## wherein R.sub.3, R.sub.4, R.sub.5 and X have the significance given hereinabove, with a compound which forms a carbonium ion of the formula ##STR3## wherein R.sub.1 and R.sub.2 have the significance as given hereinabove.

REFERENCES:
patent: 3965105 (1976-06-01), Zenitz
European Patent Specification No. 333, (6-16-78).
Krauch et al., Reactionen der Organischen Chemie, (1976), pp. 103-105.
Mathieu et al., Formation of C-C Bonds, vol. II (1975), pp. 312 and 335.
Olah, Friedel-Crafts and Related Reactions, vol. II, pt. 1 (1964), pp. 576-577.
Olah, Friedel-Crafts and related Reactions, vol. III, pt. 2 (1964), pp. 1230--1231.
Volkou et al., Do Klady Akademii Nauk, SSSR, 133 (1960), pp. 869-872.
Morrison et al., Organic Chemistry, 2nd Ed. (1970), pp. 375-377.

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