Process for the preparation of morphinane derivatives

Details Process for the preparation of morphinane derivatives Process for the preparation of morphinane derivatives

1989-09-12

1991-12-10

Rivers, Diana G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 44, C07D48908

Patent

active

050719858

ABSTRACT:
The invention relates to a process for the preparation of morphinane derivatives of general formula: ##STR1## by demethylation of 3-methoxylated compound with a sulfonic acid selected from methanesulfonic acid and trifluoromethanesulfonic acid in the presence of a sulfide.

REFERENCES:
patent: 4265890 (1981-05-01), Holden et al.
patent: 4707483 (1987-11-01), Bondinell et al.
Kiso et al., Chemical Abstracts, vol. 92: 198745n (1980).
Irie et al., Chemical Abstracts, vol. 93: 186623d (1980).
Bentley, "The Chemistry of the Morphine Alkaloids", Oxford, at the Clarendon Press, 1954, pp. 60, 406, and 413.

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