Process for the preparation of mivacurium chloride

Details Process for the preparation of mivacurium chloride Process for the preparation of mivacurium chloride

2011-01-18

2011-01-18

Davis, Zinna N (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07872137

ABSTRACT:
A process for preparing the [R—[R*,R*-(E)]]-2,2′-(1,8-dioxo-4-octene-1,8-diyl) bis(oxy-3,1-propanediyl)bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl) methyl]isoquinolinium) dichloride, commonly known as mivacurium chloride, useful as short-duration neuromuscular blocking agent.

REFERENCES:
patent: 4761418 (1988-08-01), Swaringen, Jr. et al.
Tuba et al. “Synthesis and Structure-Activity Relationships of Neuromuscular Blocking Agents,” Current Medicinal Chemistry, vol. 9, No. 16, Aug. 2002 (Abstract Only).

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