Process for the preparation of microspheres made of a biodegrada

Details Process for the preparation of microspheres made of a biodegrada Process for the preparation of microspheres made of a biodegrada

1992-07-16

1995-08-29

Warden, Jill

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 424490, 424497, 424499, 514 2, 514 16, 514 15, 514 12, A61K 3800

Patent

active

054458323

ABSTRACT:
The process is aimed at providing a composition designed for the sustained and controlled release of medicamentous peptide substances, obtained in the form of microspheres of a biodegradable polymeric material incorporating said medicamentous substance.
It consists in converting first a water-soluble peptide or peptide salt into a water-insoluble peptide, respectively peptide salt. The following steps include preparing an organic-aqueous emulsion and then extracting the organic solvent in an excess of aqueous medium.

REFERENCES:
patent: 4010125 (1977-03-01), Schally et al.
patent: 4622244 (1986-11-01), Lapka et al.
patent: 4675189 (1987-06-01), Kent et al.
patent: 4767628 (1988-08-01), Hutchison
patent: 4954298 (1990-09-01), Yamamoto
patent: 5192741 (1993-03-01), Orsilini
Chang, "Biodegradable Semipermeable Microcapsules Containing Enzymes, Hormones, Vaccines and Other Biologicals", J. Bioeng. 1 (1976) p. 25.
Langer, "Controlled Release of Macromolecules", Chemtech Feb. 1982 pp. 98-105.
Hutchison et al., "Biodegradable Carriers for the Sustained Release of Polypeptides", TIBTECH Apr. 1987 (vol. 5) pp. 102-106.
Chemical Abstracts, vol. 107, No. 13, Abstract 109765g (1987).

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