Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1999-01-13
2000-03-21
Harrison, Robert H.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424489, 424499, 514 54, 514866, A61K 916
Patent
active
060399708
ABSTRACT:
The present invention is directed to a microsphere for the controlled release of a biologically active molecule which comprises a biologically active molecule and an ester of hyaluronic acid or mixtures of said esters of hyaluronic acids, and wherein said biologically active molecule is surrounded by or adhered to said ester of hyaluronic acid, and wherein said microsphere has a diameter of between 1 .mu.m to 100 .mu.m.
REFERENCES:
patent: 4462983 (1984-07-01), Azria et al.
patent: 4847091 (1989-07-01), Illum
patent: 4853226 (1989-08-01), Machida et al.
patent: 4904479 (1990-02-01), Illum
patent: 4925673 (1990-05-01), Steiner
patent: 4946870 (1990-08-01), Partain, III et al.
patent: 4965353 (1990-10-01), della Valle et al.
patent: 5008116 (1991-04-01), Cahn
patent: 5073543 (1991-12-01), Marshall et al.
patent: 5108759 (1992-04-01), Ranney
patent: 5204108 (1993-04-01), Illum
patent: 5629011 (1997-05-01), Illum
patent: 5707644 (1998-01-01), Illum
patent: 5804212 (1998-09-01), Illum
patent: 5833891 (1998-11-01), Subramaniam et al.
patent: 5856299 (1999-01-01), Righetto et al.
patent: 5874029 (1999-02-01), Subramaniam et al.
patent: 5879359 (1999-03-01), Dorigatti et al.
patent: 5939323 (1999-08-01), Valentini et al.
Greissman et al, Intensive Care Med 22:495-499 (1996).
Illum, "Microspheres As a Potential Controlled Release Nasal Drug Delivery System," pp. 205-210.
Fisher et al., J. Pharm. Pharmacol. 37:38-41 (1985).
Sugibayashi et al., Biomaterials 1982, vol. 3, pp. 181-186 (Jul.).
Ratcliffe et al., J. Pharm. Pharmacol. 36:431-436 (1984).
Alphabetical List of Compounds.
Davis et al., "Microspheres as Controlled-Release Systems for Parenteral and Nasal Administration", pp. 201-213.
Illum et al., International Journal of Pharmaceutics, 46:261-265 (1988).
Bodmeier et al., Pharmaceutical Research, vol. 6, No. 5, 1989.
Hermens et al., Pharmaceutical Research, vol. 7, No. 2, 1990.
Illum et al., International Journal of Pharmaceutics, 39:189-199 (1987).
M. Bendetti et al., Journal of Controlled Release, 13:33-41 (1990).
Langer, Science, 249:1527-1533 (1990).
Benedetti Luca
Callegaro Lanfranco
Romeo Aurelio
FIDIA S.p.A.
Harrison Robert H.
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