Process for the preparation of microgranules suitable for suspen

Details Process for the preparation of microgranules suitable for suspen Process for the preparation of microgranules suitable for suspen

1994-01-28

1995-10-24

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424470, A61K 914

Patent

active

054608287

ABSTRACT:
The object of the invention is a process for the preparation of microgranules to be used in controlled-release liquid pharmaceutical compositions. Operating with high-shear mixer-granulators within clearly established crucial parameter ranges, this process results in microgranules having a particle size distribution, a density, a surface and a shape which make them particularly suitable for coating and then suspension in fluids.

REFERENCES:
patent: 4886669 (1989-12-01), Ventouras
patent: 4948589 (1990-08-01), Ilijima et al.
patent: 5043167 (1991-08-01), Rotini et al.
patent: 5296236 (1994-03-01), Santus et al.
Gaillard, C. et al., Eur. J. Pharm. Biopharm. 38(5):163-168, 1992.
Database WPI, Abstract, AN 88-326816 & JP-A-63 240 934, (Taisho Pharmaceut KK) Oct. 6, 1988.
Database WPI, Abstract, AN 76-83997X & JP-A-51 106 712, (Takeda Chemical IND KK) Sep. 22, 1976.

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