Process for the preparation of microcrystalline cisplatin

Details Process for the preparation of microcrystalline cisplatin Process for the preparation of microcrystalline cisplatin

1980-09-29

1982-03-30

Sneed, Helen M. S.

Chemistry of inorganic compounds

Treating mixture to obtain metal containing compound

Alkali metal

C01D 700, C22B 2610

Patent

active

043223915

ABSTRACT:
A stable, microcrystalline form of cisplatin, a process for its preparation, and stable, sterile dry-mix formulations thereof which are more rapidly reconstituted with sterile water to produce solutions suitable for intravenous administration to man than are similar formulations containing "regular" cisplatin. The microcrystalline cisplatin and dry-mix formulations thereof are prepared without the use of lyophilization.

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Kauffman et al., Inorganic Synthesis, McGraw-Hill Book Co. Inc., N.Y., pp. 239-245 (1963).
Breusova-Baidala et al., Akademia Nauk SSSR, No. 6, pp. 1167-1169 (1974).
Reishus et al., Journal of The American Chem. Soc. 83, 2457-2462 (1961).
Handelsman et al., Clinical Brochure, Cis Platinum (II) Diammine dichloride, Nat. Can. Inst., pp. 31 and 32 (1974).
Talley et al., Cancer Chemotherapy Reports, 57, 465-471 (1973).
Rosenberg et al., Nature 222, 385-386 (1966).

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